Atmospheric Chemistry Program Seminar

Impact of relative humidity on reactive uptake of glyoxal (CHOCHO) onto aerosol over the Korean peninsula during the KORUS-AQ 2016 by Dongwook Kim,
ANYL 1st year, CU Boulder
"Glyoxal (CHOCHO) plays an important role in secondary organic aerosol (SOA) formation through aqueous phase chemistry. However, the heterogeneous processes and resulting glyoxal contribution to total SOA in various ambient conditions are largely unknown. In this study, the impact of humidity and irradiation on uptake of gaseous glyoxal onto particulate matter in has been investigated based on the glyoxal measurement acquired from airborne Cavity Enhanced Absorption Spectrometer (CEAS), during KORUS-AQ field campaign, with the help of 0-dimensional box model where the parameters were constrained by the observations from DC-8. The reactive uptake coefficient of glyoxal (γ) was derived by reconciling the gap between the observation of glyoxal and the expected abundance of glyoxal estimated from the steady-state box model without the uptake process. In the presence of > 0.1 ppb of glyoxal, the OA growth rate from glyoxal uptake was estimated to be 0.48 μg/m3/hour and γ varied from 0-20x10-3 having median and mean values of 5.89x10-3 and 8.10x10-3, respectively. The typical lifetime of glyoxal during the campaign was estimated to be ~37 minutes. γ decreased at 25-35% RH range which can be explained partially by the salting-in effect. On the other hand, γ increased at 35-75% RH range which remains uncertain. Also, γ showed an increasing trend with increasing irradiation indicating that the irreversible uptake process is dominant at the highly irradiated conditions."
and
The Synthesis of Two Novel p-38α Inhibitors by Hannah Maben,
ANYL 1st year, CU Boulder
"Current p-38α inhibitors are in clinical trials to treat diseases such as cancer, Rheumatoid arthritis, and Crohn’s disease. The synthesis of two potential p-38α inhibitors, bis-1,3-(4,6-difluoro-4-{4-[quinoxalin-2- ylmethoxy]methyl}-1H-1,2,3-triazol-1-yl]pyridin-2-yl) 5-methyl-6-phenylpiperazine-2,3-dicarbonitrile (I) and 2,6-di(5,6-Dimethyl-6,7-dihydro-5H-[1,2,5]oxadiazolo[3,4-b]pyrazin-4-yl)-3,5-difluoro-4-(4-phenyl- [1,2,3]triazol-1-yl)-pyridine (II) were conducted. The syntheses involved several nucleophilic aromatic substitution (S N Ar) reactions, a Sharpless “click” reaction, and a mild reduction via sodium borohydride. All products and intermediates were sent for elemental and biological testing, and two intermediates were determined to have biological activity against colon cancer."